SGK1 acts as a "hub" molecule regulating diverse cellular processes:
: The human SGK1 protein is a serine/threonine-protein kinase consisting of 431 amino acids with a molecular mass of approximately 49 kDa . It features an N-terminal PX-like (phox homology) domain, a central catalytic kinase domain, and a C-terminal hydrophobic motif. SGK1 4 zip
: It inhibits apoptosis by phosphorylating and inactivating pro-apoptotic factors like FOXO3a and p53 . SGK1 acts as a "hub" molecule regulating diverse
: Excessive SGK1 activity is linked to chronic inflammatory conditions and tissue fibrosis in the heart, lungs, and kidneys. Clinical Relevance a central catalytic kinase domain
then phosphorylates Threonine 256 within the kinase domain.