The official PC port is known for being technically unstable, but modern community fixes at PCGamingWiki can make it playable:
There is no legitimate Game Boy or Game Boy Advance version of Prototype 2. prototype-2-pc-game-highly-compressed-gameboy
The search for a " Prototype 2 PC game highly compressed Game Boy" version reveals that Prototype 2 is a high-end open-world title originally released for PC, PlayStation 3, and Xbox 360. 1. The Myth of the "Game Boy" Version The official PC port is known for being