You will not receive security patches or new features through the Google Play Store. You would have to manually find and install a new "modded" file for every update.
The version you mentioned is labeled as a It is important to understand the implications of using modified software instead of the official version: Nova Launcher-Prime-v801_build_80001-Modapk
Modded APKs are often altered by third parties to bypass licensing (getting Prime features for free). This process can easily inject malware, spyware, or keyloggers into the app. You will not receive security patches or new