Standard Wine often struggles with 64-bit-only macOS. Use the Gcenx macOS Wine builds or a tool like Wineskin Winery .

Look for wine-stable or wine-devel 64-bit packages.

Most modern Linux distributions include 64-bit support by default, but you should ensure both architectures are available for maximum compatibility.

Once Wine is installed, you don't "open" Wine; you use it to open your Windows file.