Atopy <2026 Update>

The core of atopy is a Type I hypersensitivity reaction driven by a Type 2 immune response.

Atopy is a genetic predisposition toward developing exaggerated IgE-mediated immune responses to common environmental allergens. Clinically, it manifests as a triad of conditions—, allergic rhinitis (hay fever) , and allergic asthma —often appearing sequentially in a pattern known as the "atopic march". 1. Pathophysiology and Mechanism The core of atopy is a Type I

: Sensitization through inflamed skin can lead to early-onset food allergies. allergic rhinitis (hay fever)

: Antigen-presenting cells perceive allergens (like pollen or dust mites) as danger signals, activating TH2 or ILC2 cells. activating TH2 or ILC2 cells.