: The trial established dronedarone as a rhythm-control therapy specifically aimed at reducing clinical complications rather than just maintaining sinus rhythm. 2. Dronedarone (Multaq) Usage Guide
Stop other Class I or III antiarrhythmics (e.g., amiodarone, sotalol) before starting Multaq. Avoid strong (e.g., ketoconazole). ATHENA HEART [310]
: To determine if dronedarone could lower the risk of hospitalization due to cardiovascular events or death from any cause in patients with atrial fibrillation (AF) or atrial flutter (AFL). : The trial established dronedarone as a rhythm-control
: Monitor serum creatinine levels; small increases are common but should be assessed if they persist. ATHENA HEART [310]
Patients with paroxysmal or persistent AF or AFL who are in sinus rhythm or who will be cardioverted.